The Science Behind the Product
Active Ingredient: Benzoyl Peroxide (BPO) 9.48%. This hardworking pimple fighter has been proven effective in treating acne by killing the Propionibacteria acnes bacteria responsible for outbreaks. However, irritation is a common problem when BPO is not dissolved or delivered effectively.
In response to this problem Dimethyl Isosorbide (DMI) was designed to help dissolve actives such as BPO in formulations and prevent its re-agglomeration (act or process of gathering into a mass). This increases the efficacy of BPO by limiting its particle size to better target the pores and eliminate the source of acne. Further, by keeping the particles from re-agglomerating, it reduces skin irritation. It is generally known that actives are only as effective as the vehicles used to deliver them. DMI is designed to aid penetration into the epidermis by increasing the polarity of the surface skin layers to carry the active BPO to the pores of the skin in order to kill the bacteria that cause acne, where it can act more effectively.
In fact, the ingredient was shown to be a better delivery vehicle for BPO than Ethoxydiglycol (EDG) a commonly used competitive material, as determined experimentally and in a theoretical model comparing the polarity of the delivery vehicle to the solute, in this case BPO.
It was found that more than double the amount of BPO can be dissolved in Dimethyl Isosorbide than in such competitive delivery vehicles. In addition, Dimethyl Isosorbide ensures BPO has maximum contact time with the pores and acne-causing bacteria. However, it was not shown to promote penetration into the bloodstream. DMI, a methylated sorbitol derivative, enhances the activity of BPO while reducing its skin irritation potential. This material increases the effectiveness of actives in formulations.